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Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa

South Africa, 2015
Non-communicable Disease
Kim A. Nguyen, Nasheeta Peer, Andre P. Kengne
Created on January 18, 2021 Last modified January 18, 2021 Page views 12243 Documentation in PDF Metadata DDI/XML JSON
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Identification

Survey ID Number
GGTandcardio-metabolicdiseases
Title
Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa
Country
Name Country code
South Africa ZAR
Abstract
Backgound: Gamma-glutamyl transferase (GGT) has recently been reported as a biomarker for cardiovascular (CVD) risk in general populations. We investigated the associations of GGT with cardio-metabolic diseases and CVD risk in South Africans living with HIV.
Methods: In this cross-sectional study, HIV-infected adults were randomly recruited across 17 HIV clinics in the Western Cape Province. Homeostatic model assessment for insulin resistance (HOMA-IR), hypertension, diabetes, metabolic syndrome by Joint Interim Statement criteria (JIS-MS), a =5% and =10% predicted risk for a CVD event within 10 years by the Framingham risk score (10-years-CVD risk) were computed. Associations between GGT and cardio-metabolic trait were explored using linear and binomial logistic regressions adjusted for age, gender, lifestyle behaviours and HIV-related characteristics.
Results: Among 709 participants (561 women, mean age 38.6 years), log-GGT was positively associated with waist circumference (ß=2.75; p<0.001), diastolic blood pressure (ß=1.65; p=0.006), total cholesterol (ß=0.21; p<0.001), low-density lipoprotein-cholesterol (ß=0.16; p<0.001), high-density lipoprotein-cholesterol and log-triglycerides (both ß=0.12; p<0.001), fasting plasma glucose (ß=0.19; p=0.031), 2-hour-post-glucose-load plasma glucose (ß=0.26; p=0.007), HOMA-IR (ß=0.13; p=0.001), log-high-sensitivity C-reactive-protein (ß=0.3; p<0.001) in linear regression analyses; with hypertension [OR=1.41 (95%CI, 1.13-1.75); p=0.001], JIS-MS [OR=1.33 (1.05-1.68); p=0.016], =5% 10-year-CVD risk [OR=1.55 (1.24-1.9400); p<0.001] and =10% 10-year-CVD risk [OR=1.56 (1.08-2.23); p=0.016] but not with diabetes [OR=1.24 (0.88-1.71), p=0.205] in logistic regression analyses.
Conclusions: In this study, GGT levels were associated with cardio-metabolic variables independent of HIV specific attributes. If confirmed in longitudinal studies, GGT evaluation maybe included in CVD risk monitoring strategies in people living with HIV.

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Primary investigators
Name Affiliation
Kim A. Nguyen Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town and Durban, South Africa
Nasheeta Peer Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town and Durban, South Africa
Andre P. Kengne Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town and Durban, South Africa

Data Collection

Dates of Data Collection
Start End
2015-01-01 2015-12-31
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